Gunning Group

HDAX Therapeutics

Postdoctoral Fellow – Medicinal/Synthetic Chemistry

HDAX Therapeutics is a Mississauga-based drug discovery startup developing targeted therapeutics for cancers and neuropathies. We engineer small molecules that provide on-target effects and have minimal off-target toxicity, and exquisite brain penetration properties, creating a platform for the safe and efficacious treatment of a range of difficult diseases.

This position is in partnership with Prof Patrick Gunning at the University of Toronto Mississauga and Centre of Medicinal Chemistry (CMC). The Gunning Group is one of the leaders in the fields of molecular recognition and medicinal chemistry with a strong record of academic publications, patents and commercialization. The laboratory has an extensive and global network of academic, industrial, and governmental collaborators. Our group offers a highly dynamic and innovative research environment with pharma-quality services and instruments.

Job description

HDAX Therapeutics is recruiting a full-time postdoctoral fellow in the area of synthetic/medicinal chemistry. The candidate will participate in research projects focusing on design, synthesis, and biological testing of novel small molecule therapeutics.

Job Title: Postdoctoral fellow

Number of openings: 1

Position start date: Fall 2022

Job site: University of Toronto, 3359 Mississauga Rd, Mississauga Ontario L5L 1C6

Status: Full-time, 12-24 months contract

Desired skills and experience

The candidates should have completed their PhD degree in organic chemistry, medicinal chemistry, or a related discipline. The successful candidate will be highly motivated, goal oriented and a self-driven individual who is ready to work independently as well as in a team environment. The ideal candidate has experience in organic synthesis to support preclinical development of drug candidates.


• PhD in Organic, Bioorganic or Medicinal Chemistry or related discipline.

Preferred Qualifications

• Comprehensive and up-to-date knowledge of synthetic organic chemistry (background in drug discovery is preferred but not necessary)

• Troubleshoot and optimize reaction sequences and conduct multi-step synthesis with full characterization of molecules

Collection, analysis and interpretation of data sets and proposal of follow-up syntheses/experiments based on data trends

• Strong skills in written and oral communication

• Ability to work effectively both independently and as a member of a team

Interested candidates are asked to submit a CV and a cover letter to

This position is open to applicants legally authorized to work in Canada, and can start working in Fall 2022. Strong preference will be given to individuals who are Canadian residents, permanent residents, work permit holders or citizens.

HDAX Therapeutics Inc. is an equal opportunity employer, and we are committed to achieving accessibility by providing accommodation for people with disabilities during our hiring process. Accommodation is available on request for qualified candidates during the recruitment process.