Bioanalytical Chemistry, Materials Chemistry, Clinical Chemistry, Biosensors, single-molecule assays, cryogenic transmission electron microscopy, bioinspired nanomaterials, disease diagnostics
Dr. Alana Ogata’s lab will innovate single-molecule bioanalytical sensors for multi-component protein analysis with direct applications in disease diagnostics and pathology. Her research program interfaces analytical, materials, and clinical chemistry to drive technology development and clinical translation. Her lab focuses on bioinspired nanomaterials development, single-molecule bioanalytical sensors, and simple and rapid diagnostics; creating a diagnostics pipeline to address unmet clinical needs in healthcare. Dr. Ogata’s long-term vision is to transform women’s health and develop diagnostics for gynecological diseases.
Dr. Ogata believes in dedicated mentorship, and that skills in independent research, leadership, communication, and diversity & inclusion are necessary for student growth. She looks forward to working with chemists, material scientists, biomedical and chemical engineers, and MD-PhDs, and creating a team centered around empathy, accountability, and learning to drive research innovations.
Van Houten, Justin; Dosjah, Advikaa; Ogata, Alana F.*; Mutliplexed Electrochemial Detection of Biomarkers in Biological Samples. Royal Society of Chemistry Specialist Reports. 2023. in press
Eric J.Choi, Nicholas P. Drago, Nicholas Humphrey, Justin Van Houten, Il-Doo Kim*, Alana F. Ogata*, Reginald M. Penner*. "Electrodeposition-Enabled, Electrically-Transduced Sensors and Biosensors: 2017 - Present". Materials Today. 2023. 62, 129-150. https://doi.org/10.1016/j.mattod.2022.11.021.
Gilboa, Tal; Ogata, Alana F; Reilly, Charles B; Walt, David R. Single-molecule studies reveal method for tuning the heterogeneous activity of alkaline phosphatase. Biophysical Journal. 2022. 121, 1-8. https://doi.org/10.1016/j.bpj.2022.05.005
Carpenter, Brooke P; Talosig, Rain A; Mulvey, Justin T; Merham, Jovany G; Esquivel, Jamie; Rose, Ben; Ogata, Alana F; Fishman, Dmitry A; Patterson, Joseph P. Role of Molecular Modifications and Protein Folding in the Nucleation and Growth of Protein-Metal Organic Frameworks. Chemistry of Materials. 2022. 34, 18, 8336-8344. https://doi.org/10.1021/acs.chemmater.2c01903
Gibson, Christopher J.; Kim, Haesook T.; Zhao, Lin; Murdock, H. Moses; Hambley, Bryan, Ogata, Alana F; Madero-Marroquin, Rafael; Wang, Shiyu; Green, Lisa; Fleharty, Mark; Dougan, Tyler; Cheng, Chi-An; Blumestiel, Brendan; Cibulskis, Carrie; Tsuji, Junko; Duran, Madeline; Gocke, Christopher, D.; Antin, Joseph H.; Lennon, Niall, J.; Walt, David R., Ritz, Jerome; Soiffer, Robert J.; Gondek, Lukasz P.; Lindsley, R. Coleman. Donor Clonal Hematopoiesis and Recipient Outcomes After Implantation. Journal of Clinical Oncology. 2022, 40 (2), 189-201. https://doi.org/10/1200/JCO.21.02286
Ogata, Alana F; Lazarovits, Roey; Uwamanzu, Agusta; et al. Detection of SARS-CoV-2 Antibodies in Diagnosis and Treatment of COVID-19. Clinics in Laboratory Medicine. 2021, 42 (1) 97.
Gilboa, Tal: Ogata, Ogata, Alana F, Walt, David R. Single-molecule enzymology for diagnostics: profiling alkaline phosphate activity in clinical samples. ChemBioChem. 2021.23 (1) e2021100358 https://doi.org/10.1002/cbic.202100358
Ogata, Alana Fα, Cheng, Chi-Anα; Desjardins, Michaelα et al. Circulating SARS-CoV-2 Vaccine Antigen Detected in the Plasma of mRNA-1283 Vaccine Recipients. Clinical Infectious Diseases. 2021. https://doi.org/10.1093/cid/ciab465.
Yonker, Lael Mα; Gilboa Talα; Ogata, Alana Fα,; et al. Multisystem inflammatory syndrome in children is driven by zonulin-dependent loss of gut mucosal barrier. Journal of Clinical Investigation. 2021. 10.1172/JCI149633.
Ogata, Alana F Maley, Adam M; Wu, Connie; Gilboa, Tal; Norman, Maia; et al. Ultra-sensitive Serial Profiling of SARS-CoV-2 Antigens and Antibodies in Plasma to Understand Disease Progression in COVID-19 Patients with Severe Disease. Clinical Chemistry. 2020. https://doi.org/10.1093/clinchem/hvaa213.
Ogata, Alana F Mirabello, G; Rakowski, Alexander M; Patterson, Joe P. Chapter 7: Revealing Nonclassical Nucleation Pathways using Cryogenic Electron Microscopy; Crystallization via Nonclassical Pathways Volume 1: Nucleation, Assembly, Observation & Application. ACS Symposium Series. 2020, 1385, 147-200.
Norman, Maia; Gilboa, Tal; Ogata, Alana F Maley, Adam M; Cohen, Limor; et al. Ultra-Sensitive High-Resolution Profiling of Anti-SARS-CoV-2 Antibodies for Detecting Early Seroconversion in COVID-19 Patients. Nat. Biomed. Eng. 2020. https://doi.org/10.1038/s41551-020-00611-x.
Gilboa, Talα; Maley, Adam Mα; Ogata, Alana Fα,; Wu, Connieα; Walt, David R. Sequential Protein Capture in Multiplex Single Molecule Arrays: A Strategy for Eliminating Assay Cross-Reactivity. Advanced Healthcare Materials. 2020. https://doi.org/10.1002/adhm.202001111.