Microdosing is more popular than ever, but we still don’t really understand how it works and what it does. There has been a recent groundswell of journalism on the topic, but there is almost no scientific evidence for the effects of this practice. We are preparing a study that will measure the empirical effects of microdosing. Our design will be a double-blind placebo-controlled crossover washout trial. We aim to have 100 participants in our first study.