The cyclin-dependent kinase inhibitor roscovitine inhibits kinase activity, cell proliferation, multicellular development, and Cdk5 nuclear translocation in Dicytyostelium discoideium

For a second week in a row we recognize the work of Ph.D. student Robert Huber from the O’Day lab.

Robert's paper was recently published in the Journal of Cellular Biochemistry. In this paper, Robert confirms the role of Cdk5 in cell proliferation, and determines that the nuclear translocation of Cdk5 is likely the primary target of the drug. This work also gives clues to how roscovitine might affect other organisms.

Amazing productivity, Robert! Keep it up!

Read this paper