Hai-Ying Mary Cheng
-
E-mail:
-
Phone:
-
Fax:
-
Website:
-
Room:DV 3044
Canada Research Chair in Molecular Genetics of Biological Clocks
Education
- B.Sc.(hons) in Biochemistry, University of Calgary
- M.Sc., Medical Biophysics, University of Toronto (1999)
- Ph.D., Medical Biophysics, University of Toronto (2003)
Research
My research interest is in Animal Biology; more specifically, neurobiology and physiology; circadian clock mechanisms in mammals; and genetic determinants of adult neurogenesis. My lab is currently focusing on two areas of research:
Adult Neurogenesis
- Our laboratory is interested in the effects of genetic ablation on various stages of SGZ neurogenesis, including cell proliferation, apoptosis, differentiation and neuronal maturation, and the fascinating mechanisms that underlie adult SGZ neurogenesis.
Circadian Rhythms
- The overall objective of our laboratory is to elucidate the cellular mechanisms that regulate biological timing in mammals, and, in turn, to understand how these cellular mechanisms manifest themselves at the “organism” scale such as animal behaviour, and play a role in diseases arising from their abnormal functioning.
Become a Lab Member
We are currently recruiting graduate students and post-doctoral fellows. Please email a CV and contact details for three references directly to Dr. Cheng (haiying.cheng@utoronto.ca).
Serious graduate candidates should subsequently apply to the University of Toronto Department of Cell & Systems Biology (CSB) graduate program. Admission requirements can be found through the CSB page, here.
Recent Publications
For a complete list of publications, please visit Dr. Cheng's Google Scholar page.
- Boehler NA, Seheult SDI, Wahid M, Hase K, D’Amico SF, Saini S, Mascarenhas B, Bergman ME, Phillips MA, Faure PA, Cheng HM. A novel copy number variant in the murine Cdh23 gene gives rise to profound deafness and vestibular dysfunction. Hum Mol Genet. 2024 Jul 9:ddae095. doi: 10.1093/hmg/ddae095. Online ahead of print.
- Luo Z, Zhuang K, Kim SJ, Vollett KDW, Lou Z, Wang J, Cheng HM, Khazaei M, Fehlings MG, Cheng HL. Longitudinal MRI Tracking of Transplanted Neural Progenitor Cells in the Spinal Cord Utilizing the Bright Ferritin Mechanism. Stem Cells Transl Med. 2024 Mar 8:szae016. doi: 10.1093/stcltm/szae016.
- Yu Y, Liu JY, Yang, HJ, Luo XX, Gao XP, Huang XX, Tang AX, Cheng HM, Liu WC, Zhang P. Circadian disruption during fetal development promotes pathological cardiac remodeling in male mice. iScience. 2024 Jan 26;27(2):109008. doi: 10.1016/j.isci.2024.109008. eCollection 2024 Feb 16.
- Zhuang K, Romagnuolo R, Valdman TS, Vollett KDW, Szulc DA, Cheng HM, Laflamme MA, Cheng HL. Bright ferritin for long-term MR imaging of human embryonic stem cells. Stem Cell Res Ther. 2023 Nov 14;14(1):330. doi:10.1186/s13287-023-03565-4.
- Jett KA, Baker ZN, Hossain A, Boulet A, Cobine PA, Ghosh S, Ng P, Yilmaz O, Barreto K, DeCoteau J, Mochoruk K, Ioannou GN, Savard C, Yuan S, Abdalla OHMH, Lowden C, Kim BE, Cheng HM, Battersby BJ, Gohil VM, Leary SC. Mitochondrial dysfunction reactivates alpha-fetoprotein expression that drives copper-dependent immunosuppression in mitochondrial disease models. J Clin Invest. 2023 Jan 3;133(1):e154684. doi:10.1172/JCI154684.
- Abdalla OHMH, Mascarenhas B, Cheng HM. Death of a protein: the role of E3 ubiquitin ligases in circadian rhythms of mice and flies. Int J Mol Sci. 2022;23(18):10569. doi.org/10.3390/ijms231810569.
- Faykoo-Martinez M, Collins T, Peragine D, Malik M, Javed F, Kolisnyk M, Ziolkowski J, Jeewa I, Cheng AH, Lowden C, Mascarenhas B,, Cheng HM, Holmes MM. Protracted neuronal maturation in a long-lived, highly social rodent. PLOS ONE. 2022 Sep 15;17(9):e0273098.
- Xu LN, Li HT, Liu S, Jiang J, Liu YQ, Cheng HM, Yu Y, Cao JM, Zhang P. Constitutional delay of growth and puberty in female mice is induced by circadian rhythm disruption in utero. Ecotoxicol Environ Saf. 2022 Aug;241:113723.
- Hegazi S, Cheng AH, Krupp JJ, Tasaki T, Liu J, Szulc DA, Ling HH, Rios Garcia J, Seecharran S, Basiri T, Amiri M, Anwar Z, Ahmad S, Nayal K, Sonenberg N, Liu BH, Cheng HLM, Levine JD, Cheng HM. UBR4/POE facilitates secretory trafficking to maintain circadian clock synchrony. Nature Commun. 2022 Mar 24;13:1594.
- Cheng AH, Fung SW, Hegazi S, Abdalla OHMH, Cheng HM. Sox2 regulates neuronal differentiation of the suprachiasmatic nucleus. Int J Mol Sci. 2022;23(1):229. doi: 10.3390/ijms23010229.
- Boehler NA, Fung SW, Hegazi S, Cheng AH, Cheng HM. Sox2 ablation in the suprachiasmatic nucleus perturbs anxiety- and depressive-like behaviors. Neurol Int. 2021 Oct 26;13(4):541-554.
- Lowden C, Boulet A, Boehler NA, Seecharran S, Rios Garcia J, Lowe NJ, Liu J, Ong JLK, Wang W, Ma L, Cheng AH, Senatore A, Monks DA, Liu BH, Leary SC, Cheng HM. Homeostatic control of nuclear-encoded mitochondrial gene expression by the histone variant H2A.Z is essential for neuronal survival. Cell Rep. 2021 Sep 14;36(11):109704. doi: 10.1016/j.celrep.2021.109704.
- Cheng AH, Cheng HM. Genesis of the master circadian pacemaker in mice. Front Neurosci. 2021 Mar 23. doi.org/10.3389/fnins.2021.659974.
- Szulc DA, Lee XA, Cheng HM*, Cheng HM. Bright ferritin – a reporter gene platform for on-demand, longitudinal cell-tracking on MRI. iScience. 2020 Jul 9;23(8):101350. doi: 10.1016/j.isci.2020.101350.
- Piekut T, Wong YY, Walker SE, Smith CL, Gauberg J, Harracksingh AN, Lowden C, Novogradac BB, Cheng HM, Spencer GE, Senatore A. Early metazoan origin and multiple losses of a novel clade of RIM pre-synaptic calcium channel scaffolding protein homologues. Genome Biol Evol. 2020 May 15:evaa097. doi: 10.1093/gbe/evaa097.