Danton H. O'Day

Professor Emeritus Danton O’Day has continued his research into calmodulin and its binding proteins during the onset and progression of Alzheimer’s disease (AD). He has compiled extensive data validating the Calmodulin Hypothesis of AD originally proposed with Dr. Mike Myre. Since 2020, he has published a dozen refereed papers extending the Calmodulin Hypothesis to neurodegeneration in general and with specific relevance to amyotrophic lateral sclerosis, frontotemporal lobar dementia, Huntington’s disease, Parkinson’s disease and traumatic brain injury. His work provides insight into why it has been impossible to develop therapies to treat the physiological and neurological events involved in AD and provides a primary target offering a potentially universal therapy.

Dan has also published several books on Artists of the Rubaiyat of Omar Khayyam along with 13 videos on Women Artists uploaded to his YouTube channel “DantonCanada”. In January 2025, he completed his donation of Rubaiyat of Omar Khayym Book Collection, consisting of over 600 books plus Omariana, to the UTM library.

Recent Publications

• O’Day, D.H. The Complex Interplay between Toxic Hallmark Proteins, Calmodulin-Binding Proteins, Ion Channels, and Receptors Involved in Calcium Dyshomeostasis in Neurodegeneration. Biomolecules 2024, 14, 173. doi: 10.3390/biom14020173
• O’Day, D.H. Calcium and Non-Penetrating Traumatic Brain Injury: A Proposal for the Implementation of an Early Therapeutic Treatment for Initial Head Insults. Biomolecules2024, 14, 853. doi: 10.3390/biom14070853
• O’Day, D.H. The Search for a Universal Treatment for Defined and Mixed Pathology Neurodegenerative Diseases. Int. J. Mol. Sci. 2024, 25, 13424. https://doi.org/10.3390/ijms252413424
• O’Day, D. H. (2025). The calmodulin hypothesis of neurodegenerative diseases: searching for a common cure. Neurodegenerative Disease Management, 1–3. https://doi.org/10.1080/17582024.2025.2488230