Aiyan Brown's first authored paper on measuring the structure and dynamics of single molecules

Experimental methods have advanced to be able to measure the structure and dynamics of single molecules such as proteins. One of the most common tools we use for these measurements is light; by attaching dyes to the molecule of interest, we can infer its conformations using a technique known as smFRET. In hopes of making this technique more quantitative, in this work Aiyan Brown outline a novel computational approach to simulating smFRET which markedly improves the efficiency and resolution of calculations. This allows for accurate insights into the effects that various physical phenomena can have on these measurements and provides a toolkit which one can use to aid in interpreting experimental results.

Brown, A., & Gradinaru, C. (2026). Parsing contributions of physical phenomena to smFRET statistical inhomogeneity via multiparameter stochastic simulations. The Journal of Chemical Physics, 164(14). https://doi.org/10.1063/5.0315927.