Molecular modulators of the circadian clock: lessons from flies and mice

Grad students and personnel in Mary Cheng's lab
Monday, May 1, 2017 - 7:59am

Are you curious to know more about how our behavior and physiology are tightly synchronized to daily environmental cycles? Or, why do we suffer from jet lag when traveling between different time zones? You’ll find these answers and more in the recent paper “Molecular modulators of the circadian clock: lessons from flies and mice” published by co-first authors Lucia Mendoza-Viveros, Pascale Bouchard-Cannon and Sara Hegazi (Cheng group) in Cellular and Molecular Life Sciences. This paper provides an extensive overview of the intricate molecular mechanisms underlying circadian timekeeping in Drosophila and murine systems. Their paper explores the clock’s response to temporal cues in the environment, highlighting the full spectrum of factors that influence the function of core clock components at the various levels of gene expression and regulation. This paper also serves to identify challenges and gaps in chronobiological research that are worthy of further investigation to enhance our understanding of biological timekeeping and of the intimate relationship between the clock and human health. Co-authors on this paper include Arthur Cheng and Stephen Pastore.

Congratulations, Cheng Lab – you guys rock!