James B. Anderson, Ph.D., University of Vermont, 1980

Professor, Departments of Cell & Systems Biology and Ecology & Evolutionary Biology, University of Toronto and Deptartment of Biology, University of Toronto Mississauga

3359 Missisauga Road North, Mississauga, Ontario L5L 1C6 CANADA

phone: 905-828-5362

fax: 905-828-3792

Research Interests

Fungal genetics, population biology, and evolution

Ongoing Research

Population genetics and evolution of fungi. I am interested in the processes that shape the structure of fungal populations including sexual and somatic recognition, reproduction, mutation and recombination. To investigate the impact of these natural processes in populations, our research uses the tools of molecular genetics, genomics, and evolutionary biology. Current research includes the following:

Photos of fungi here.


Advanced Genetics (BIO341F) and Molecular Biology (BIO372S)

Lab Personnel

Lucas Parreiras, Graduate student

Stefan Catona, Graduate Student

David Bartfai, Graduate Student

Cindy Short, Research Assistant

Former Lab personnel

Selected Publications

Anderson, JB, Funt, J, Thompson, DA, Prabhu, S, Socha, A, Sirjusingh, C, Dettman, JR, Parreiras, L, Guttman, DS, Regev, A, and Kohn, LM. Determinants of divergent adaptation and Dobzhansky-Muller interaction in experimental yeast populations. Current Biology 20:1383-1388.

Dettman, JR, Anderson, JB, and Kohn, LM. 2010.  Genome-wide investigation of reproductive isolation in experimental lineages and natural species of Neurospora: identifying candidate regions by microarray-based genotyping and mapping. Evolution 64:694-709

Selmecki, AM, Dulmage, K, Cowen, LE, Anderson, JB, and Berman, J. 2009. Acquisition of aneuploidy provides increased fitness during the evolution of antifungal drug resistance. PLoS Genet 5 (10), e1000705.

Anderson, JB., Sirjusingh, C, Syed,N, and LaFayette S.  2009. Gene expression and evolution of antifungal drug resistance.  Antimicrobial Agents and Chemotherapy 53:1931-1936.

Dettman JR, Anderson JB, and Kohn, LM. 2008. Divergent adaptation promotes reproductive isolation among
experimental populations of the filamentous fungus Neurospora
. BMC Evolutionary Biology 2008, 8:35

Kohn LM, Schaffer MR, Anderson JB, and Grünwald N. 2008. Marker stability throughout 400 days of in vitro hyphal growth in the filamentous ascomycete, Sclerotinia sclerotiorum.  Fungal Genetics and Biology 45:613-617.

Dettman JR, Sirjusignh S, Kohn LM and Anderson JB. 2007. Incipient speciation by divergent adaptation and antagonisitc epistasis in yeast. Nature 447:585-588.

Anderson JB and Kohn LM.  2007. Dikaryons, diploids and evolution.  ASM volume:  Sex in fungi: molecular determination and evolutionary implications.  Edited by Heitman J, Casselton L, Taylor, J. W., and Kronstad J.

Anderson JB, Ricker N, and Sirjusingh C. 2006. Antagonism between two mechanisms of antifungal drug resistance.  Eukaryotic Cell 5:1243-1251.

Anderson JB. 2005. Evolution of antifungal-drug resistance: mechanisms and pathogen fitness. Nature Reviews Microbiology 3:547-556.

Anderson JB, Sirjusingh S, and Ricker N. 2004. Haploidy, diploidy and evolution of antifungal drug resistance in Saccharomyces cerevisiae. Genetics 168:1915-1923.

Clark TA and Anderson JB. 2004. Dikaryons of the basidiomycete fungus Schizophyllum commune: evolution in long-term culture. Genetics 167:1663-1675.

Anderson JB, Sirjusingh C, Parsons AB, Boone C, Wickens C, Cowen LE, and Kohn LM . 2003. Mode of selection and experimental evolution of antifungal drug resistance in Saccharomyces cerevisiae. Genetics 163:1287-1298..

Cowen LE, Nantel A, Whiteway MS, Thomas DY, Tessier DC, Kohn LM, and Anderson JB. 2002. Population Genomics of Drug Resistance in Candida albicansProceedings of the National Academy of Sciences (USA) 99:9284-9289. 

Cowen LE, Anderson JB, and Kohn LM. 2002. Evolution of drug resistance in Candida albicans. Annual Review of Microbiology 56:139­165.

Cowen L, Kohn LM, and Anderson JB. 2001. Fitness divergence associated with the evolution of drug resistance in experimental populations of Candida albicans. Journal of Bacteriology 183:2971-2978.

Anderson JB, Wickens C, Khan M, Cowen LE, Federspiel N, Jones T, and Kohn LM. 2001. Infrequent genetic exchange and recombination in the mitochondrial genome of Candida albicans. Journal of Bacteriology 183:865-872 (data here).

Cowen LE, Sanglard D, Calabrese D, Anderson JB, and Kohn LM. 2000. Evolution of drug resistance in experimental populations of Candida albicans. Journal of Bacteriology 182:1515-1522.

Hodnett B and Anderson JB. 2000. Genomic stability of two individuals of Armillaria gallica. Mycologia 92:894-899.

Cowen LE, Sirjusingh C, Summerbell RC, Walmsley S, Richardson S, Kohn LM , and Anderson JB 1999. Multilocus Genotypes and DNA fingerprints do not predict variation in azole resistance among isolates of Candida albicans. Antimicrobial Agents and Chemotherapy. 1999 12:2930-2938.

Carbone I, Anderson JB, and Kohn LM. 1999. Patterns of descent in clonal lineages and their multilocus fingerprints are resolved with combined gene genealogies. Evolution 53:11-21.

Anderson JB and Kohn LM. 1998. Genotyping, gene genealogies and genomics bring fungal population genetics above ground. Trends in Ecology and Evolution 13: 444-449.

Saville BJ, Kohli Y, and Anderson JB. 1998. Mitchondrial DNA recombination in a natural population. Proceedings of the National Academy of Sciences (USA). 95:1331-1335.

Xu JP, Kerrigan RW, Horgen PA, and Anderson, JB. 1997. Genetic structure of natural populations of Agaricus bisporus, the commercial button mushroom. J. Heredity 88:482-494.

Saville BJ, Yoell H, and Anderson JB. 1996. Genetic exchange and recombination in populations of the root-infecting fungus Armillaria gallica. Molecular Ecology 5:485-497.

Anderson JB and Kohn LM. 1995. Clonality in soilborne, plant-pathogenic fungi. Annual Review of Phytopathology 33:369-391.

Carvalho D and Anderson JB. 1995. Genetic exchange between diploid and haploid mycelia of Armillaria gallica. Mycological Research 99:641-647.

Kerrigan RW, Royer J, Baller L, Kohli Y, Horgen PA, and Anderson JB. 1993. Meiotic behavior and linkage relationships in the secondarily homothallic fungus, Agaricus bisporus. Genetics 133:225-236.

Smith ML, Bruhn JN, and Anderson JB. 1992. The fungus Armillaria bulbosa is among the largest and oldest living organisms. Nature 356:428-431.

Anderson JB and Stasovski E. 1992. Molecular phylogeny of Northern hemisphere Armillaria species. Mycologia 84:505-516.

Smith ML, Duchesne L, Bruhn JN, and Anderson JB. 1990. Mitochondrial genetics in a natural population of the plant pathogen Armillaria. Genetics 126:575-582.


Web Design: Jim Anderson URL: http://www.erin.utoronto.ca/~janderso Revised: Nov. 28, 2007.