Zovkic, Iva

Assistant ProfessorPsychology

Contact Information

Phone: 
905-828-3961
Room: 
CC 4071
Mailing Address: 
3359 Mississauga Rd.
City: 
Mississauga
Province: 
ON
Postal Code: 
L5L 1C6
image of Iva

Area of Research

Behavioural neuroscience, neurobiology, learning and memory, fear conditioning, systems consolidation, plasticity, epigenetics, histone variant exchange, chromatin, rodents

Profile

My research focuses on the neurobiological mechanisms through which transient experiences produce persistent behavioral outcomes. Memory formation is a primary example of a general phenomenon in behavioural science, whereby transient life experiences are transformed to produce long-lasting changes in the brain, and ultimately, in behaviour. Epigenetic mechanisms, which provide a bridge between environmental stimuli and gene regulation, have the potential to act as stable molecular marks required to support memory formation and maintenance over a lifetime.

Epigenetic modifications regulate access to DNA, which is obscured by its packaging into nucleosomes that consist of two each of histones H2A, H2B, H3, and H4. Nucleosome composition can be altered through the exchange of canonical histones with their replication-independent variants that differentially regulate DNA access and transcription. I recently demonstrated that histone H2A.Z, a variant of histone H2A, is actively exchanged during memory consolidation in both the hippocampus and the cortex, where it acts as a restraint on the formation of recent and remote memory. These findings introduce histone variant exchange as a novel epigenetic regulator of memory formation and transcription in the nervous system.

My interests center on elucidating the regulatory role of nucleosome composition and histone variant exchange in cognition, particularly in the context of co-occurring epigenetic modifications. Histone variants are an especially exciting target for memory stabilization because of our recent observation that cortical H2A.Z binding at memory-associated genes is altered long after the cessation of the learning event. Thus, studies aimed at uncovering the mechanisms through which histone exchange is regulated and in turn, how it regulates its downstream targets over time, can provide essential insights into the molecular basis of memory. To this end, my research focuses on multiple stages of memory formation, including initial and transient consolidation events in the hippocampus, as well as the gradual transfer of memories to the cortex in a process termed systems consolidation.

An important consideration in studies focused on any single modification is that epigenetic modifications do not occur in isolation and instead work together to regulate gene expression and, ultimately, behaviour. I am especially interested in understanding the coordinated effects of histone variants, post-translational modifications and DNA methylation in regulating memory formation and memory maintenance. These related lines of research converge on the broader issue of stimulus-induced plasticity in neural networks and their implications for establishing persistent behavioural outcomes.

Publications

Walters BJ, Azam AB, Gillon CJ, Josselyn SA, Zovkic IB (2016) Advanced in-vivo use of CRISPR/Cas9 and anti-sense DNA inhibition for gene manipulation in the brain. Frontiers in Genetics, 6, 362-375.

Zovkic I & Sweatt, JD (2015) Memory-associated Dynamic Regulation of the “Stable” Core of the Chromatin Particle, Neuron, 87, 1-4.

Walters BJ & Zovkic I (2015) Building up and knocking down: An emerging role for epigenetics and proteasomal degradation in systems consolidation, Neuroscience, 300, 39-52. (Cover article)

Zovkic I & Walters BJ (2015) H2A.Z helps genes remember their history so we can remember ours. BioEssays, 37, 596-601.

Zovkic I, Paulukaitis B, Etikala D, Day JJ. & Sweatt, JD (2014) H2A.Z subunit exchange controls consolidation of recent and remote memory. Nature, 515, 582-586.    

Zovkic I, Meadows J & Sweatt JD (2013). Epigenetic mechanisms of PTSD. Frontiers in Psychiatry, 4, 60 

Zovkic I, Guzman-Karlsson M & Sweatt JD (2013). Epigenetic regulation of memory formation and maintenance. 
Learning & Memory, 20, 61-74. – Journal Cover

Zovkic I & Sweatt, JD (2013). Epigenetic mechanisms in learned fear: Implications for PTSD. 
Neuropsychopharmacology, 38, 77-93
Mathews (Zovkic) I & McCormick CM (2012). Role of medial prefrontal dopamine in age differences in response to 
amphetamine in rats: Locomotor activity after intra-mPFC injections of dopaminergic ligands. Developmental Neurobiology, 72, 1415-1421

McCormick CM, Thomas CM, Sheridan C, Nixon F, Flynn JA & Mathews (Zovkic) I (2011). Social instability stress in 
adolescent male rats alters hippocampal neurogenesis and produces deficits in spatial location memory in 
adulthood. Hippocampus, 22, 1300-1312

Mathews (Zovkic) I, Brudzynski SM & McCormick CM (2011) Heightened locomotor-activating effects of 
amphetamine administered into the nucleus accumbens in adolescent rats. International Journal of Developmental Neuroscience, 29, 501-507

Mathews (Zovkic) I, Kelly H & McCormick CM (2011). Low doses of amphetamine lead to immediate and lasting 
locomotor sensitization in adolescent, not adult, male rats. Pharmacology, Biochemistry and Behavior, 97, 640-646

Morrisey MD, Mathews (Zovkic) I, & McCormick CM. (2010). Enduring deficits in contextual and auditory fear 
conditioning after adolescent, not adult, social instability stress in male rats. Neurobiology of Learning & 
Memory, 95, 46-56

Mathews (Zovkic) I, Morrissey MD, & McCormick CM (2010). Individual differences in activity predict locomotor 
activity and conditioned place preference to amphetamine in both adolescent and adult rats. Pharmacology, Biochemistry, and Behaviour, 95, 63-71.

McCormick CM & Mathews (Zovkic) I. (2010). Adolescent development, hypothalamic-pituitary-adrenal function, and 
programming of adult learning and memory. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 34, 756-765.

McCormick CM, Mathews (Zovkic) I, Thomas C, & Waters PG (2010). Investigations of HPA function and the enduring 
consequences of stressors in adolescence in animal models. Brain & Cognition, 72, 73-85. 

Mathews (Zovkic) I, Waters PG & McCormick CM (2009). Changes in       hyporesponsiveness to acute amphetamine and 
age differences in tyrosine hydroxylase immunoreactivity in the brain over adolescence in male and female rats. Developmental Psychobiology, 51, 417-428. 

Mathews (Zovkic) I, Wilton A, Styles A & McCormick CM (2008). Increased depressive behaviour in females and 
heightened corticosterone release in males to swim stress after adolescent social stress in rats. Behavioural Brain Research, 190, 33-40.

Mathews (Zovkic) I, Mills R & McCormick CM (2008). Chronic social stress in adolescence influenced both 
amphetamine conditioned place preference and locomotor sensitization. Developmental Psychobiology, 50, 451-459. 

McCormick CM, Smith C & Mathews (Zovkic) I (2008). Effects of chronic social stress in adolescence on anxiety and 
neuroendocrine response to mild stress in male and female rats. Behavioural Brain Research, 187, 228-238. 

Mathews (Zovkic) I, & McCormick CM (2007). Female and male rats in late adolescence differ from adults in 
amphetamine-induced locomotor activity, but not in conditioned place preference for amphetamine. Behavioural Pharmacology, 18, 641-50.

McCormick CM & Mathews (Zovkic) I (2007). HPA function in adolescence: Role of sex hormones in its regulation and 
the enduring consequences of exposure to stressors. Pharmacology, Biochemistry, and Behavior, 86, 220-233. 

Other

Education: 
B.A. (Psychology: Brock University)
Ph.D. (Psychology: Behavioural Neuroscience, Brock University)
Postdoctoral fellowship (Neurobiology: University of Alabama at Birmingham)