Our lab focuses on studying the organization and dynamical motion of chromosomal and plasmid DNA. While being intimately involved in genetic function, the packaging and arrangement DNA has operational effects that are not well understood at present. Errors in gene expression, besides arising from mistakes in the code itself, could also manifest by macromolecules that over-twist or over-stretch the DNA, problems in packing within the nucleus, long-range interference between genes, and so on. While challenging to address, these questions have the potential to define a new paradigm for our understanding of how living cells function.
NEWS (01/11/16): We are looking for a graduate student to join the lab. If you are a new physics student at U of T, and interested in single-molecule biophysics and optical trapping, contact me .
NEWS (08/09/16): Our article "Xenogeneic silencing and its impact on bacterial genomes" is now online in the Annual Reviews of Microbiology .
NEWS (24/08/16): A preprint of our latest article "Molecular counting with localization microscopy: A redundant labeling approach", is now available online at bioRxiv.org.
NEWS (09/08/16): Our article "Quantitative localization microscopy reveals a novel organization of a high-copy number plasmid" is now available in the Biophysical Journal .
NEWS (01/05/16): Danielle, Paul and Daniel have joined the lab for the summer as ROP students. They'll be working on cell sorting with microfluidics.
NEWS (17/03/16): Emily, Daniel and Richard are in the U of T News for their efforts at tracking plasmid uptake with a microfluidic device.
NEWS (01/03/16): The final version of our Bioinformatics article is now available: "Fast Optimized Cluster Algorithm for Localizations (FOCAL): A Spatial Cluster Analysis for Super-Resolved Microscopy ".
NEWS (21/01/16): Dr. Yong Wang has left our group to start his own lab in the Department of Physics at the University of Arkansas. Best of luck Yong! (Wang Lab Website)