Our lab focuses on studying the organization and dynamical motion of chromosomal and plasmid DNA. While being intimately involved in genetic function, the packaging and arrangement DNA has operational effects that are not well understood at present. Errors in gene expression, besides arising from mistakes in the code itself, could also manifest by macromolecules that over-twist or over-stretch the DNA, problems in packing within the nucleus, long-range interference between genes, and so on. While challenging to address, these questions have the potential to define a new paradigm for our understanding of how living cells function.
NEWS (20/12/16): We are looking for 1-2 graduate students to join the lab. If you are a new physics student at U of T, please contact me .
NEWS (18/12/16): A preprint of our mini-review "Resolving biology beyond the diffraction limit with single-molecule localization microscopy" is available at bioRxiv.org. The published version will appear in a special issue of Physics in Canada on Nanoscale Approaches to Biological Systems.
NEWS (08/09/16): Our article "Xenogeneic silencing and its impact on bacterial genomes" is now online in the Annual Reviews of Microbiology .
NEWS (24/08/16): A preprint of our latest article "Molecular counting with localization microscopy: A redundant labeling approach", is now available online at bioRxiv.org.
NEWS (09/08/16): Our article "Quantitative localization microscopy reveals a novel organization of a high-copy number plasmid" is now available in the Biophysical Journal .