Our lab focuses on studying the dynamical motion of DNA, which, while being intimately involved in genetic function, has operational effects that are not well understood at present. Errors in genetic expression, besides arising from mistakes in the code itself, could also manifest by macromolecules that over-twist or over-stretch the DNA, problems in packing within the nucleus, long-range interference between genes, and so on. Studying the dynamics of DNA, while challenging, has the potential to define a new paradigm for our understanding of cellular function, which could have a range of implications for our understanding of health and disease.NEWS (10/01/14): Our paper on chromsome packaging by H-NS: "A biomechanical mechanism for initiating DNA packaging," was published in Nucleic Acids Research (available online ahead of print).
NEWS (9/4/14): Russell just passed his M.S. defense and is continuing in the lab as a Ph.D. student. Excellent!!
NEWS (8/23/14): Looking for a graduate student to work on Super-Resolution Imaging starting in the Fall of 2014. Please contact Dr. Joshua Milstein directly if interested.
NEWS (7/23/14): A Fast Temporal Median Filter plugin for ImageJ is now freely available on the Research page of our website (scroll down). This is a very useful tool for removing background noise that can degrade STORM/PALM image reconstructions.
NEWS (6/24/14): Dr. Yong Wang joined the lab as a Human Frontiers Science Program (HFSP) Fellow to work on super-resolution imaging of bacterial dynamics.
NEWS (6/18/14): Nafiseh Rafiei was just awarded an OGS Graduate Fellowship. Congratulations!
NEWS (6/6/14): Our paper "Rapid Feedback Control and Stabilization of an Optical Tweezers with a Budget Microcontroller," was accepted in Eur. J. Phys.