Our lab focuses on studying the dynamical motion of DNA, which, while being intimately involved in genetic function, has operational effects that are not well understood at present. Errors in genetic expression, besides arising from mistakes in the code itself, could also manifest by macromolecules that over-twist or over-stretch the DNA, problems in packing within the nucleus, long-range interference between genes, and so on. Studying the dynamics of DNA, while challenging, has the potential to define a new paradigm for our understanding of how living cells function.
NEWS (15/11/15): Emily won 3rd place in the poster competition at the 2015 Canadian Undergraduate Physics Conference.
NEWS (10/11/15): An advance access version of our new article in Bioinformatics is available: "Fast Optimized Cluster Algorithm for Localizations (FOCAL): A Spatial Cluster Analysis for Super-Resolved Microscopy ".
NEWS (04/11/15): New in PLoS ONE "Simulation Assisted Analysis of the Intrinsic Stiffness for Short DNA Molecules Imaged with Scanning Atomic Force Microscopy ".
NEWS (28/10/15): Just out in Optics Express " Improved axial trapping with holographic optical tweezers ".
NEWS (24/10/15): Emily just won a UTM Undergraduate Research Grant for her work on focal spot engineering.
NEWS (10/09/15): We have had a number of students join the lab. Daniel is a new Physics PhD student, Shubham and Rachel are undergraduate ROP students, and Aoife is an exchange student from Cardiff University.
NEWS (16/07/15): Our lab was featured in the UofT news again (link).
NEWS (16/06/15): Our latest paper " Axial Optical Traps: A New Direction for Optical Tweezers " is now available online in the Biophysical Journal.