Our lab focuses on studying the organization and dynamical motion of chromosomal and plasmid DNA. While being intimately involved in genetic function, the packaging and arrangement DNA has operational effects that are not well understood at present. Errors in gene expression, besides arising from mistakes in the code itself, could also manifest by macromolecules that over-twist or over-stretch the DNA, problems in packing within the nucleus, long-range interference between genes, and so on. While challenging to address, these questions have the potential to define a new paradigm for our understanding of how living cells function.



NEWS (09/15/17): Josh was awarded the inaugural UTM Annual Research Prize in the Sciences.

NEWS (09/11/17): Zheng Zhang and Tianyi Ma joined the lab as new MSc Physics students. Welcome!

NEWS (09/11/17): Minah and Faiyza are our newest ROP students for the 2017/18 academic year.

NEWS (08/06/17): A preprint of Russ's article on "Polarization effects and the calibration of a donut beam axial optical tweezers for single-molecule force spectroscopy" is now available at the bioRxiv.

NEWS (09/05/17): Daniel's and Nafiseh's article Molecular Counting with Localization Microscopy: A Bayesian estimate based on fluorophore statistics" was just published in the Biophysical Journal.