Our lab focuses on studying the dynamical motion of DNA, which, while being intimately involved in genetic function, has operational effects that are not well understood at present. Errors in genetic expression, besides arising from mistakes in the code itself, could also manifest by macromolecules that over-twist or over-stretch the DNA, problems in packing within the nucleus, long-range interference between genes, and so on. Studying the dynamics of DNA, while challenging, has the potential to define a new paradigm for our understanding of cellular function, which could have a range of implications for our understanding of health and disease.NEWS (12/01/14): Looking for an exceptional graduate student to start in the Summer/Fall of 2015. Please contact Dr. Joshua Milstein directly if interested.
NEWS (11/27/14): Stephen Havlick just started in the lab as a new M.Sc. student.
NEWS (11/4/14): Our research has been featured in the UofT News: "Superbugs: searching for weapons in the fight against drug-resistant bacteria".
NEWS (10/01/14): Our paper on chromsome packaging by H-NS: "A biomechanical mechanism for initiating DNA packaging," was published in Nucleic Acids Research (available online ahead of print).
NEWS (9/4/14): Russell just passed his M.S. defense and is continuing in the lab as a Ph.D. student. Excellent!!
NEWS (7/23/14): A Fast Temporal Median Filter plugin for ImageJ is now freely available on the Research page of our website (scroll down). This is a very useful tool for removing background noise that can degrade STORM/PALM image reconstructions.
NEWS (6/24/14): Dr. Yong Wang joined the lab as a Human Frontiers Science Program (HFSP) Fellow to work on super-resolution imaging of bacterial dynamics.
NEWS (6/18/14): Nafiseh Rafiei was just awarded an OGS Graduate Fellowship. Congratulations!
NEWS (6/6/14): Our paper "Rapid Feedback Control and Stabilization of an Optical Tweezers with a Budget Microcontroller," was accepted in Eur. J. Phys.