Research

Research Collaborations:

Ron Nachman, USDA, College Station, Texas, USA – Peptide analogs

Celia Carlini, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil – Plant ureases and their effects in Rhodnius prolixus.

Chariston Chariston A. Dal Belo, Universidade Federal do Pampa-UNIPAMPA - Plant toxins and their effect on the neuromuscular junction.

Jozef Vanden Broeck, University of Leuven, Leuven, Belgium- GPCRs

Guy Smagghe, University of Ghent, Belgium – Peptides and feeding

Recent Publications:

Patel, H., Orchard, I., Veenstra, J.A. and Lange, A.B. (2013) The distribution and physiological effects of three evolutionarity and sequence-related neuropeptides in Rhodnius prolixus: adipokinetic hormone, corazonin and adipokinetic hormone/corazonin-related peptide.  General and Comparative Endocrinology (In press).

Lee, D.H., Orchard, I. and Lange, A.B. (2013) Evidence for a conserved CCAP-signalling pathway controlling ecdysis in a hemimetabolous insect, Rhodnius prolixus.  Frontiers in Neuroendocrine Science (In press).

Lee, D.H., Vanden Broeck, J. and Lange, A.B. (2013) Identification and expression of the CCAP receptor in the Chagas' disease vector, Rhodnius prolixus, and its involvement in cardiac control. PLoS ONE 8(7): e68897

Sedra, L. and Lange, A.B. (2013) Musculature and effects of FMRFamide-like peptides in the female reproductive system of the blood-gorging bug, Rhodnius prolixus.  Peptides (In press).

Robertson, L., Rodriguez, E.P. and Lange, A.B. (2012) The neural and peptidergic control of gut contraction in Locusta migratoria: the effect of an FGLa/AST.  J. Exp. Biol. 215:3394-3402.

Lange, A.B., Alim, U., Vandersmissen, H.P., Mizoguchi, A., Vanden Broeck, J. and Orchard, I. (2012) The distribution and physiologicl effects of the myoinhibiting peptides in the kissing bug, Rhodnius prolixus. Front. Neurosci. 6:98.

da Silva, R., da Silva, S.R. and Lange, A.B. (2012) The regulation of cardiac activity by nitric oxide (NO) in the Vietnamese stick insect, Baculum extradentatumCellular Signalling 24:1344-1350. (this article was written up in the Entomological Society of Canada Blog, June 15, 2012.)

Lee, D., Taufique, H., da Silva, R. and Lange, A.B. (2012) An unusual myosuppressin from the blood-feeding bug, Rhodnius prolixus. J. Exp. Biol. 215:2088-2095.

Orchard, I. and Lange, A.B. (2012) Advances in insect physiology and endocrinology through genomics, peptidomics, and related technologies.  Can. J. Zool. 90:435-439.

Malik, A., Gäde, G. and Lange, A.B. (2012) Sequencing and biological effects of an adipokinetic /hypertrehalosemic peptide in the stick insect, Baculum extradentatumPeptides 34:51-56.

Lee, D. and Lange, A.B. (2011) Crustacean cardioactive peptide in the Chagas’ disease vector, Rhodnius prolixus: presence, distribution and physiological effects.  Gen. Comp. Endocrinol. 174:36-43.

Orchard I., Lee D.H., da Silva R., and Lange A.B. (2011).  The proctolin gene and biological effects of proctolin in the blood-feeding bug, Rhodnius prolixus. Front. Neuroendocrinol. 2: 59.

da Silva, S.R., da Silva, R. and Lange, A.B. (2011) Effects of crustacean cardioactive peptide on the hearts of two Orthopteran insects, the demonstration of a Frank-Starling-like effect.  Gen. Comp. Endocrol. 171:218-224.

Lee, D.H., Paluzzi, J.P., Orchard, I. and Lange, A.B. (2011) Isolation, cloning and expression of the Crustacean Cardioactive Peptide gene in the Chagas’ disease vector, Rhodnius prolixus.  Peptides 32:475-482.

da Silva, R. and Lange, A.B. (2011) Evidence of a central pattern generator regulating spermathecal muscle activity in Locusta migratoria and its coordination with oviposition.  J. Exp. Biol. 214:757-763.

 

Recent Conference Abstracts:

Robertson, L. Donini, A. and Lange, A.B. FGLa/AST action at the locust hindgut: The role of two FGLa/ASTs on muscle contraction and K+ transport.  Insect Biotech Conference, June 5, 2013.

Lee, D. and Lange, A.B. The functional analysis of neuropeptide crustacean cardioactive peptide and its receptor in ecdysis behaviour of Rhodnius prolixus. Insect Biotech Conference, June 5 – 8, 2013.

Patel, H. and Lange, A.B. Distribution and physiological effects of adipokinetic hormone (AKH), corazonin and AKH/corazonin-related peptide (ACP) in the kissing bug, Rhodnius prolixus. Insect Biotech Conference, June 5 – 8, 2013.

Sedra, L. and Lange, A.B. Myoinhibitors in the blood-gorging insect, Rhodnius prolixus. Insect Biotech Conference, June 5 – 8, 2013.

Paluzzi, J.P. and Lange, A.B. Functional characterization and transcript expression profile of the myoinhihbiting peptide receptor in the blood-feeding Hemipteran, Rhodnius prolixus. Insect Biotech Conference, June 5 – 8, 2013.

Paluzzi, JP and Lange, A.B. Identification, expression analysis and functional characterization of the myoinhibiting peptide receptor in the Chagas disease vector, Rhodnius prolixus.  2nd North American Society of Comparative Endocrinology Meeting, Queretero, Mexico, May 2013.

Lee, D.H., Orchard I, and Lange AB. The crustacean cardioactive peptide and its receptor in the kissing bug, Rhodnius prolixus.   2nd North American Society of Comparative Endocrinology Meeting, Queretero, Mexico, May 2013.

Nguyen, H., Lange, A.B. and Orchard, I.  Increased NaCl transport mediates synergism between serotonin and the diuretic peptide RhoprCRF/DH in the medically-important disease vector Rhodnius prolixus.  Canadian Society of Zoologists Annual Meeting, Guelph, May 13-17, 2013.

Paluzzi, J.-P, and Lange, A.B. Functional characterization and expression analysis of the myoinhibiting peptide receptor in the haematophagous hemipteran, Rhodnius prolixus.  Canadian Society of Zoologists Annual Meeting, Guelph, May 13-17, 2013.

Patel, H. and Lange, A.B. Distribution and physiological effects of adipokinetic hormone (AKH), corazonin and AKH/corazonin-related peptide (ACP) in the kissing bug, Rhodnius prolixus. Canadian Society of Zoologists Annual Meeting, Guelph, May 13-17, 2013.

Sedra, L. and Lange, A.B. Muscle morphology and a possible role of FMRFamide-like peptides (FLPs) on reproduction within the kissing bug, Rhodnius prolixus. Canadian Society of Zoologists Annual Meeting, Guelph, May 13-17, 2013.

Orchard, I. and Lange, A.B.  The Kiss of Death: Rhodnius prolixus, neurohormones, and the transmission of Chagas’ disease. GIST International Symposium for Invertebrate Neuropeptides and GPCRs, Gwangju, Korea, August 2012. INVITED TALK

Lange, A.B. The distribution and physiological effects of neuropeptides controlling reproductive tissues in the kissing bug, Rhodnius prolixus. XXIV International Congress of Entomology, Daegu, Korea, August 2012. - INVITED TALK

Lee, D.H., Lange, A.B, and Orchard, I. The proctolin gene and actions of proctolin in the blood-feeding bug, Rhodnius prolixus.  XXIV International Congress of Entomology, Daegu, Korea, August 2012.

Orchard I. and Lange A.B. Diuretic and antidiuretic strategies in Rhodnius prolixus. Society for Experimental Biology Annual Meeting, Salzburg, Austria, June 2012

Robertson, L. and Lange, A.B. The neural and peptidergic control of locust gut contraction: The effect of FGLa/ASTs. Insect Biotech Conference Annual Scientific Meeting, St Catharines, June 6-8, 2012.

Lee, D. and Lange, A.B. Action sof crustacean cardioactive peptide in Rhodnius prolixus.  Insect Biotech Conference Annual Scientific Meeting, St Catharines, June 6-8, 2012.

Sedra, L. and Lange, A.B.  FMRFamide-like peptides (FLPs) associated with muscle fibers in Rhodnius reproductive tissue. Insect Biotech Conference Annual Scientific Meeting, St Catharines, June 6-8, 2012.

Lange, A.B., and Orchard, I. Proctolin in Rhodnius prolixus. Rhodnius consortium meeting, La Plata, Argentina, May 2012.

Orchard, I., and Lange, A.B. Diuretic and antidiuretic strategies in Rhodnius prolixus. Rhodnius consortium meeting, La Plata, Argentina, May 2012.

Lange, A.B., Lee, D., Taufique, H. and da Silva, R. An unusual myosuppressin from the blood-feegin bug, Rhodnius prolixus.  Invertebrate Neuropeptide Conference, San Pedro de Atacama, Chile, Feb. 2012.

da Silva, R.. da Silva, S.R.C. and Lange, A.B. The regulation of insect cardiac activity and a Frank-Starling-like mechanism.  The inaugural meeting of the North American Society for Comparative Endocrinology.  Ann Arbor, July 2011.

Lee, D.H., Orchard, I. and Lange, A.B. The crustacean cardioactive peptide and its receptor in the kissing bug, Rhodnius prolixus. The inaugural meeting of the North American Society for Comparative Endocrinology.  Ann Arbor, July 2011.

Robertson, L., Lange, A.B., and Donini, A.  Allatostatin inhibits locust gut contraction and ileal ion transport.  Insect Biotech Conference, St. Catharines, June 2011.

da Silva, R., da Silva, S.R. and Lange, A.B. the effects of crustacean cardioactive peptide on the hearts of two orthopteran insects, and a frank-starling-like mechanism.  Insect Biotech Conference, St. Catharines, June 2011.

Lee, D., Lange, A.B. and Orchard, I.  Proctolin in the blood-gorging bug, Rhodnius prolixus. Insect Biotech Conference, St. Catharines, June 2011.

Lee, D.H. and Lange, A.B. The crustacean cardioactive peptide and its receptor in the blood-gorging bug, Rhodnius prolixus.   Canadian Society of Zoologists 50th annual meeting, Ottawa, May 2011.

Lange, A.B. and Lee, D.H. Crustacean cardioactive peptide gene and its receptor in the blood-feeding bug, Rhodnius prolixus. Invertebrate Neuropeptide Conference, Kota Kinabalu, Borneo, February 2011.